Selective Inhibition of Thermosensitive TRPV3 Channel by Natural Coumarin Osthole for Itch Relief
نویسندگان
چکیده
منابع مشابه
Growth Inhibition and Apoptosis Induced by Osthole, A Natural Coumarin, in Hepatocellular Carcinoma
BACKGROUND Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed tumors worldwide and is known to be resistant to conventional chemotherapy. New therapeutic strategies are urgently needed for treating HCC. Osthole, a natural coumarin derivative, has been shown to have anti-tumor activity. However, the effects of osthole on HCC have not yet been reported. METHODS AND FINDINGS HC...
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1 The Ca‐permeable cation TRPV3 channel: an emerging pivotal target for itch and skin diseases Gongxin Wang and KeWei Wang Department of Pharmacology, Qingdao University School of Pharmacy and Institute of Innovative Drugs, Qingdao University, 38 Dengzhou Road, Qingdao 266021, Shandong Province, China This article has not been copyedited and formatted. The final version may differ from ...
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Intestinal ischemia/reperfusion (I/R) injury is considered to be associated with high morbidity and mortality rates. Osthole, a natural derivative of coumarin, has been shown to exert a variety of pharmacological and therapeutic effects under physiological and pathological conditions. In the present study, to investigate the protective effects of osthole against intestinal I/R injury, various d...
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Itch is the major symptom in, skin diseases with a variety of etiologies. Recent progress has been achieved in understanding the pathophysiology of itch in skin diseases. There are many) topical therapies availablte/for managingp ruritus. Emergin;g therapies include dominant ceramide moisturizers, topical immunomodulators, low pH moisturizers, topical aspirin, and combinations of moisturizers w...
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Cerebral processing of itch-scratching cycles was studied with functional magnetic resonance imaging (fMRI) in healthy volunteers. The back of the hand was repetitively scratched in the absence and presence of itch induced by histamine applied close to the scratched site. Blood-oxygenation-level-dependent (BOLD) effects were assessed in predefined cortical and subcortical brain regions of inter...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.2661